View Single Post
Old 06-17-2010, 07:46 AM
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default

Quote:
Originally Posted by GregD View Post
I tend to challenge the results of the studies on exercise for PD somewhat. I agree that exercise will help keep us fit and somewhat limber. However, when one exercises endorphins are released in the body. Endorphins make you feel good to the point some actually feel high as if they were taking a drug. Seems kind of funny to me that all of a sudden just because someone did a study now the #1 recommendation for PD is to exercise.

From en.wikipedia.org/wiki/Endorphin

Classically, μ opioid receptors are presynaptic, and inhibit neurotransmitter release; through this mechanism, they inhibit the release of the inhibitory neurotransmitter GABA, and disinhibit the dopamine pathways, causing more dopamine to be released. By hijacking this process, exogenous opioids cause inappropriate dopamine release, and lead to aberrant synaptic plasticity, which causes addiction. Opioid receptors have many other and more important roles in the brain and periphery however, modulating pain, cardiac, gastric and vascular function as well as possibly panic and satiation, and receptors are often found at postsynaptic locations as well as presynaptically.

Exercise in itself does nothing to stop or alter PD. It only tricks our bodies into a false sense of well being.
GregD
I think the ultimate goal is to replace the exerise with a drug(s) if they can find a cellular change.
the forced exercise researcher has a 2nd study planned with theracycle, he got a $500,000 grant. theracycle is sure hyping it imho.
there supposedly have been animal studies showing brain changes?

the researcher's is
Alberts, Jay and his article is
Forced, Not Voluntary, Exercise Improves Motor Function in Parkinson's Disease Patients

"Improvements in clinical measures of rigidity and bradykinesia and biomechanical measures of bimanual dexterity
were maintained 4 weeks after FE cessation".
study had 10 patients, 61yrs old or older.

it will be interesting to see what the 2nd study finds out.
soccertese is offline   Reply With QuoteReply With Quote