nOT SURE, BLOOD PRESSURE, LIVER ENZYMES AND STUFF i THINK. bUT EVERY DRUg COMES WITH A SLEW OF SIDE EFFECTS ATTACHED, WANT TO TRY THIS ONE. Novantrone and 4-Ap came with scary ones. It's in clinical trial for PPMS. Because I could not walk, trial would not accept me. I'm 54, in a chair, option to wait longer doesn't exist. Hope to get prescription and try,will pay for drug myself.