Imad,
Many neuros and MDS now believe that it is very important to keep people on as low a dose as they can while maintaining effect. I suggest that if you haven't done so already, you watch the videos, especially the second one, that Soccertese recently provided a link to, and look at how they are discussing l-dopa and the consequences of using it.

There were mistakes made in the past where people were given too much, when it was much less understood, and it resulted in long term problems. The idea should be to start low, increase gradually, and back off if there are side effects, all the time taking it very slowly.

My own neuro is very wary of increasing my dose which is currently 4 and one half tabs 100/25 plus entacapone. (that is after 7 years on it....) He constantly emphasises keep it low. Because not all the l-dopa gets absorbed a low dose can be made more available with the use of entacapone, or given in the form of Stalevo, or as CR etc....... I am not a doctor, of course, and can only recount my own experiences or reflect what we have understood from the totality of knowledge that we have gleaned over the years.

It still seems a very large dose to be starting you on..........

One possible way for you to find out more, in a direct way, without challenging anything or needing to find another doctor, is to discuss this with your pharmacist. They are often a good source of information, and can be very helpful. Also you could try contacting your local PD society, they may have advisors there. Another possibility, is that you gain access to a Parkinson's nurse specialist, if you have those in Canada. Perhaps your GP might know......

Lindy