I did Rebif for2 years, 2 tries of Novantrone with vomiting, a try of 4-AP. No huge side effects, some nausea, etc., but nothing helped. As a PPMSer, neuros didn't expect them to. Back when I believed I took my Rebif religiously but said to DH, why should I feel cruddy everyday on off chance it MIGHT help me? Now that I'm in a chair 24/7 (could not be stopped) I kick myself for wasting time when I could still walk around by taking drugs that made me feel yucky and wasted time. Honestly, they impeded me more than the chair. Now I take no drugs but am in a chair, neuro and I both know. nothing would have helped. I am still interested in fighting, want to try Fingolimod, it's for RRs, will try to get anyway. It's something for each of us to make decisions on. We are all so different. Drugs are great for some, not for me.