Like many I can only speak from my experience with Imuran. I have been on it for 4 months now and have not seen any relief of my symptoms (Yet... still have my fingers crossed tho..) I have had to reduce from 150 to 100mg and one time back to 50 mg because my white blood cell count drops to 2000 but it comes right back up, so I get blood draws every two weeks to check. Other than that I have no other side effects from Imuran.... Best of luck!