Desvenlafaxine (Pristiq) is very similar to another SNRI, Venlafaxine (Effexor). My understanding is Pristiq is a new version of Effexor.

If you have taken Effexor without any problems then it's possible you won't have a problem with Pristiq.

I used Pristiq for about 2 weeks. I was not using Pristiq for depression but trying to find something that helps with pain. Unfortunately, Pristiq increased my anxiety and caused suicidal ideation.

I found the suicide aspect confusing and scary...I didn't feel depressed. I quit taking Pristiq and the suicidal thoughts went away.

Unfortuately, I am very med sensitive and have had this reaction on other meds. Both my doctor (Psychiatrist) and myself are very hesitant about trying new meds for me.

Well, you did ask for kind or unkind reactions

I hope Pristiq works well for you