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Old 07-03-2010, 03:20 PM
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olsen olsen is offline
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Join Date: Aug 2006
Posts: 1,860
15 yr Member
olsen olsen is offline
Senior Member
olsen's Avatar
 
Join Date: Aug 2006
Posts: 1,860
15 yr Member
Default PD causative genes

(I am uncertain how many of these genes are tested via 23andme. Interesting to note the physiological mechanisms controlled by/influenced by these genes. link is for full text PDF)


Over the decade, more than 15 loci and 11 causative genes
have been identified so far and many studies shed light on
their implication in not only monogenic but also sporadic form
of PD. Recent studies revealed that PD-associated genes
play important roles in cellular functions, such as mitochondrial
functions, ubiquitin-proteasomal system, autophagylysosomal
pathway and membrane trafficking. Furthermore,
the proteins encoded by PD-associated genes can interact
with each other and such gene products may share a common
pathway that leads to nigral degeneration. However,
their precise roles in the disease and their normal functions
remain poorly understood. In this study, we review recent
progress in knowledge about the genes associated with
familial PD.

J. Neurochem. (2009) 111, 1075–1093.
http://www3.interscience.wiley.com/c...08153/PDFSTART
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