Not me, but my husband had switched from 4AP to Ampyra....but he was only taking 20mg. He describes the difference as reaching a higher level of functioning with 4AP but for a short period of time while Ampyra brings him to a lower "high" but he's able to maintain it for 12 hours.

You are taking a higher dose of 4AP than he was (and he's a big guy) so perhaps your benefit from 4AP was higher and longer-lasting than my husband's was.....

Will be interested to see if others respond....