i took it orally for 3 years before getting the infusions, started at 20mg/cc, 2-3cc's every 2 hours as needed. was on that dose till i began the infusions, then after the first one wore off my pm bumped it up to 50mg/cc, still 2-3 cc's every 2 hours as needed. its the only med that i haven't become "immune" to.