Hi All,
Good discussion and here is my two cents worth.

While I agree biomarkers as well as PD subtype classification studies would help to resolve a lot of unanswered questions and provide new information possibly from old "failed" clinical studies. This is only a start and there is a long way to go to find a cure/even disease altering therapies. We have biomarkers for diabetes, we know the cause of it.....still there is no cure.

L-DOPA may very well be toxic. At this point, there is nothing but L-DOPA and each of us have to make a decision as to if/how much we want to use.It is a compound that works in the brain, released just for a few milliseconds to exert its function and is highly regulated under normal conditions. Taking such a compound orally for extended periods of time bound to cause some damage.

Just as each one's PD is different from the next one, our treatment options are too. The best part about this forum is we get to hear all sorts of theories, treatment options and different opinions. Thats why I come here.

Girija