My experience has been the opposite. I had some side effects from Betaseron that lasted 3 months (chills). No side effects from Avonex. I have not had a flare since I started the interferons 15 years ago (knocking on wood right now). My neuro told me I am stable - which may be very different than saying the meds are actually doing their job. So maybe I'm just very, very lucky. (Plus my co-pay is only $20 and that makes a difference also.)

I don't think all drugs work for everyone or they may only work for a few. Since everyone's MS is different how the drugs work for each individual will be different as well. So they need to stop working on meds and get working on a cure or finding all of us some answers!!