Hi, kpRN -

The skin biopsy procedure is really rather benign. It is done by the punch method, same leg, either two or three sites starting just above the ankle and ending at the upper thigh. Really doesn't hurt, but the instructions for aftercare done by you is at home is important to prevent infection.

Mine was positive for non-length dependent small fiber neuropathy, and I have Sjogren's Syndrome where this type of neuropathy can occur.

Good luck,

Sheltiemom