Hi Paula, will get back with you on this tomorrow--just lost the entire posting I had with references and all my comments....ugghhh. Just FYI, CHOLINE N-acetyltransferase is an enzyme that catalyzes the reaction of acetyl CoA and choline to produce acetylcholine. there exists many "acetyltransferase" enzymes--serotonin N acetyltransferase (catalyzes serotonin to melatonin), carnitine acetyltransferase, etc. Choline acetyltransferase is specific to acetylcholine.


acetylcholine is rapidly removed by acetylcholine esterase



http://www.whatislife.com/reader2/Me...ansmitter.html

From the minimal research I did, appears that a deficiency in acetyltransferase due to genetic mutation of gene encoding this group of enzymes results in problems with detoxification/metabolization of xenobiotics--specifically toxins, pesticides and pollutants. there is no mention of effect upon neurotransmitters or other chemicals catalyzed by these enzymes.
madelyn