Anyone have any experience with Imuran?

Both my neuro and my gastro support its use for me, as I seem to be a walking example of auto-immune dysfunction. I think my body is even attacking my hair follicles sometimes!

The hope is that the Imuran will back my body's immune system off a bit and allow the inflammation to subside, at least slowing the progress if not arresting it. I would be curious if others have used immune-suppressing meds and what the experience was.