I have not searched much, so I don't know if research exists on this already. I would love to hear from anyone who knows anything related to this topic, I am very curious about this.

Firstly I am not diagnosed with MG. I suspect I have it. More on that later.

I got basic genetic testing done through 23andme and learned that I have "Two working copies of alpha-actinin-3 in fast-twitch muscle fiber. Many world-class sprinters and some endurance athletes have this genotype." Some people only have one copy and they are still in the category of "many world-class sprinters", and I guess most people have no copies of this gene thing.

I've always felt like I had this ability to "push" myself into a mode where I am much stronger. It feels different, and I always wondered if it was something that other people didn't have the ability to do... so I think it's the ACTN3.

Another thing is, many months ago I read this online "book" by a guy with MG... I don't remember the website now, and maybe someone here knows who I'm talking about. The guy was possibly named Clyde or some name starting with C but my memory is bad. Anyway the man passed away but his son was keeping the website up.

Well plenty of what he wrote really struck a chord with me. He said his own hypothesis was that many (or all) MG people had that ability to push through. I forget how he explained it, I thought his explanation was good enough for average people to understand, but I guess people on this forum will know what I mean.

One thing I am really wondering is if my ACTN3 thing would get in the way of electromyography diagnosis or other diagnosis. I feel like it would for most tests. (I'm not that sure I have MG but I know I have something with symptoms that are similar.) I read some article(s) by an MG expert who was saying lots of MG people are slipping through undiagnosed.

I would also like to hear from anyone with MG who knows they have one or two copies of this ACTN3. I think MG with it would be different than MG without. On the one hand I feel like the ACTN3 part kicks in and "compensates" but yet I feel like it's adding to the problem because when it kicks in, it's really burning energy or otherwise straining a body. I feel like if I did not have the ACTN3 then I would have been forced to seek medical help and that docs could have observed the problem and so on.

I hope some of this makes sense to somebody!