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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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Mucuna pruriens for dyskinesia
Some recent work
1. Nat Prod Res. 2010 Jul 13:1-8. [Epub ahead of print]
Mucuna pruriens attenuates haloperidol-induced orofacial dyskinesia in rats.
Pathan AA, Mohan M, Kasture AS, Kasture SB.
Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nashik,
Maharashtra, India.
Neuroleptic-induced tardive dyskinesia (TD) is a motor disorder of the orofacial
region resulting from chronic neuroleptic treatment. The agents improving
dopaminergic transmission improve TD. Mucuna pruriens seed contains levodopa and
amino acids. The effect of methanolic extract of M. pruriens seeds (MEMP) was
studied on haloperidol-induced TD, alongside the changes in lipid peroxidation,
reduced glutathione, superoxide dismutase (SOD) and catalase levels. The effect
of MEMP was also evaluated in terms of the generation of hydroxyl and
1,1-diphenyl,2-picrylhydrazyl (DPPH) radical. MEMP (100 and 200 mg kg(-1))
inhibited haloperidol-induced vacuous chewing movements, orofacial bursts and
biochemical changes. MEMP also inhibited hydroxyl radical generation and DPPH.
The results of the present study suggest that MEMP by virtue of its free radical
scavenging activity prevents neuroleptic-induced TD.
PMID: 20635303 [PubMed - as supplied by publisher]
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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