Rick,
I take my hat off to you, that is an incredible amount of work. These days, I just never seem to have the time. However I am still doing a lot of work for Kings College Hospital London, literature searches, fundraising etc.
Looking at the prescription drugs for dyskinesia, amantadine is effective , but looses its effectiveness after around 6 months of use. It is an antiviral drug, and a very similar drug is Rimantadine, with a similar structure.
Yesterday, I went to a Christening, and took half a 50mg Stavelo (25mg L-dopa) at 12-30pm. I writhed with dyskinesia until nearly 4-00pm. I can't take less than 25mg L-dopa!! Some time ago, there was no way 50mg would switch me on.
It must mean my threshold level of sensitivity to L-dopa has reduced.
Is it caused by prolonged use of curcumin, (it repairs BBB), and will I eventually not need L-dopa?
Ron