Ling,

i was told that when they evaluated cep-1347 -- they found the people on placebo did the best, and the folks on the lowest dose did the worst. I believe this was determined by the time the participants went on standard pd meds, plus all the UPDRS tests you had to go through in the trial. (I don't know if the SPECT scans came into this finding)

It was not a huge difference. But if you read the data (and understand it ....) I've been told by my doctor (who was also a researcher) that this was the case.