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Originally Posted by Mark in Idaho
From what I can find, there is no connection between the two. If pertains more to recovery/progression with cancers.
I do know that chemo brain presents similar to concussion and would likely delay healing from a concussion. The brain needs all systems working at their best for the best recovery.
I would suggest not getting to caught up in the micro details. There is a serious lack of information about the processes that relate to concussion.
The only understanding about susceptibility to concussion is based on prior concussion history. Unfortunately, there is a big unknown factor. Many concussions are not memorable either because they were dismissed as minor or they were lost in short term post traumatic amnesia. One needs to have a good understanding of concussion and subconcussive impacts to keep a reasonable mental record of concussions.
Are you struggling to understand certain symptoms or other issues?
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Some of the literature seems to indicate that low-existing dopamine in various regions of the brain, complicates recovery from TBI.(1) Dopamine levels are somewhat methylation dependent I believe, which may be influenced by genetics.
At the end of the day, it appears that dopamine is dependent on methylation. So I'm trying to seek out A) Opinion on that concept and B) If that is true, that recovering from TBI is more complex/more difficult with decreased methylation status/dopamine, does that also make one more succeptible to TBI to begin with?
(1)(J Neuropsychiatry Clin Neurosci 17:465-471, November 2005
doi: 10.1176/appi.neuropsych.17.4.465
Association of COMT Val158Met Genotype With Executive Functioning Following Traumatic Brain Injury Taken together, these findings suggest that COMT, likely associated with levels of endogenous dopamine, may possibly influence certain deficits seen in frontal-executive performance after TBI