There are plenty of ideas about neurotransmitter deficiencies. I am of the belief that before trying to impact neurotransmitters with drugs or special therapies or such, one should be sure to get normal nutritional levels balanced.

The professional field of study for this is ortho-molecular nutrition or psychiatry.

Excessive consumption of caffeine, MSG, aspartame and other excito-toxins, folic acid and B-12 deficiencies, lack of anti-oxidants, hormonal imbalances, blood sugar irregularities, poor sleep patterns, emotional and cognitive stresses can all be part of the problem.

With all of these issues that are much simpler to treat, focusing on methylation only may be getting ahead of things.

Genetic tendencies only predispose one to some of these issues. It does not suggest that more natural processes cannot correct the problem.

I know that I need high levels (over 10 times the RDA) of B-6 and B-12 to function best. Omega 3's are also indicated for brain health.

Neurotransmitters may be a big area of research currently but are not necessarily a ready for prime time science.