I took myself off DMDs 4 years ago after being on Avonex for 4 years (tired of side affects) and a few months of Copaxone (horrible side affects also).My neuro changed his whole attitude toward me when I refused to "try" another med..I haven't been back to neuro in 4 yrs.Whats the point? My PCP treats my symptoms. I feel better off the DMDs and I have not had any exaserbations, so why put my body through the stress of taking a med. that may or may not help.