Please note: Stalevo is a combination drug of carbidopa/Levodopa (Sinemet) and Entacapone (Comtan). I knew that sudden withdrawal of Sinemet or Comtan were highly dangerous.

Some of you indicated you were going to stop Stalevo, but this is not recommendned without careful watch by a professional. From the site www.rxlist.com :

Sporadic cases of a symptom complex resembling NMS have been reported in association with dose reductions or withdrawal of therapy with carbidopa-levodopa. Therefore, patients should be observed carefully when the dosage of StalevoŽ is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics. NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia. Neurological findings, including muscle rigidity, involuntary movements, altered consciousness, mental status changes; other disturbances, such as autonomic dysfunction, tachycardia, tachypnea, sweating, hyper- or hypotension; laboratory findings, such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serummyoglobin have been reported.

I imagine that replacing the Sinemet part of Stalevo would lesson the chances of this condition, but when I checked on the problems associated with stopping Comtan, I got this (from the same rxlist website):

Prescribers should exercise caution when discontinuing entacapone treatment. When considered necessary, withdrawal should proceed slowly. If a decision is made to discontinue treatment with Comtan, recommendations include monitoring the patient closely and adjusting other dopaminergic treatments as needed. This syndrome should be considered in the differential diagnosis for any patient who develops a high fever or severe rigidity. Tapering Comtan has not been systematically evaluated.

Bottom line, DO NOT STOP EITHER L-DOPA - COMTAN OR STALEVO WITHOUT BEING UNDER THE MANAGEMENT OF A DOCTOR!

And I think I now know why my dyskinesia has been worse - Comtan! (or Stalevo)

Peg