--in a word, yes.

The tests for gluten sensitivity/celiac are not foolproof; in some of the studies that JCC has accumulated in The Gluten File (which is an invlauable resources--the best database on the subject yet accumulated), up to 20% of people with proven villous atrophy tested negative on serum antibody tests for gluten. The ultimate test here often is: does one get better over time when one eliminated gluten?

As far as histamines go, I know less about that, but many, including Mrs. D, have mentioned that high histadelic people,at least, should try and avoid those foods that trigger their histamine inflammatory processes--though, as with avoiding gluten, this is often easier said than done, as many foods have hidden ingredients. It makes one quite a label reader/watcher.

People do vary greatly in their histadelic responsivity, though--there's a considerable genetic component--and some people may react hardly at all to some foods that drive others to hives (this is often behind what many call "food allergies"--there can be a histamine release even without the associated IgG or IgE antibodies that allergists tend to consider the sign of "true" allergy).