my son was on methotrexate briefly for Crohn's Disease. He absolutely hated it and refused to take it again, no would he even consider some of the other similar meds the docs wanted him on

he has had tremendous success with anti-inflammatory diet and supplements and more natural ways of controlling the autoimmunity of Crohn's....but I realize his condition is very different from what your niece is dealing with, and he is also very hypersensitive to many medications because of his multiple chemical sensitivity