I take my meds very two hours, and it has been 15 years on Sinemet, with entacapone added in about 5-6 years ago. No dramatic improvement noted, but didn't seem to hurt either. However in Canada it only comes in 200mg pills and if you take it with every dose of sinemet thats a heck of a lot of entacapone. I take 4 per day...basically every second dose. I had a friend who said it scared him because of the color of his urine. I'm considering giving it up because a lot of anything always turns out to have some side effect after a certain period of time, even a subtle one.