http://www.globes.co.il/serveen/glob...85348&fid=1725
http://www.intecpharma.com/levodopa-...s-disease.html
"Both of these phenomena are believed to be a result of the pulsatile stimulation of striatal dopamine receptors, caused by fluctuations in Levodopa blood concentrations between doses. To date, a satisfactory sustained-release formulation of Levodopa has not been possible because LD is absorbed mainly in the upper intestines and a slow release product that has passed the area of absorption is not effective. "
--------
does that explain why CR is so unpredictable, at least for me?