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Hello, Chiron: I don't know how you define "long term." I've been on Lyrica for 5-6 months, 75 mg two times per day. I put on 4-5 pounds, am short of breath (more than usual), feel tired more than before. However, I had a scorching pain -- unbearable -- in the back of my right ankle that the Lyrica has suppressed. I have other pains, moderate ones usually, sometimes severe; I'd say the Lyrica solved 60-70% of the pain problem. However, the deterioration goes on; the Lyrica has not solved that development. In short, if you are suffering from severe pains, give it a try if your M.D. says it's O.K. The first week is bad; you have to get used to Lyrica.