Rick, they did a trial with this for ALS some time ago and it appeared to shorten life span, so they nixed it. Now, perhaps if they used a lower dose, or higher, or whatever, the outcome may have been different. We can always learn from the failures and totally scrapping something may not always be best.

Aside from that, though, I think there is a lot of hesitation to look at things that, over time, can have some pretty serious side effects. I know, I know, like sinemet doesn't, but we don't have an Rx alternative to sinemet, and current thinking is that PWP don't have a choice in taking it (kudos to those who are strictly going the alternative route and I really hope it works for you), but those folk are not the majority. Heck, most neuros haven't even heard of most of the stuff talked about here.

I wish someone would look at exactly WHY minocycline helps and go at it from that angle. Has anyone used it and noticed an improvement with their PD symptoms?