I started on mestinon 3 weeks ago and was doing great on 30mg every 3 hours. After 5 days, I had to increase to 60mg every 4 hours. Worked great until about the third day when I had to take a 90mg in mid-afternoon before I could get results to improve. But, then onlly needed 30mg for rest of the evening. I am quickly learning that the dosage may need to be constantly monitored as to daily activity levels-stress, physical etc. Once I got over the 1st two week adjustment, I can tell when my body needs "more oil/gas" to get going again. LOL Best of luck.