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Originally Posted by iwasanurse
I have been on Mestinon 60 mg for about a year and a half and it seems to be losing its effect. Has anyone else experienced this?
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Hi - the way I understand things - mestinon is simply helping the nerves connect messages to the muscles. It does not affect the course of the disease. In other words, the "cures" of MG are the treatments where one gets a thymectomy, is put on prednisone, IV plasmapheris or IvIG. These treatments are the typical methods of trying to halt the MG attack of antibodies against the nerves/muscles. Ask your neuro about your treatment.