I take 25 mg at night and I have for several years since my first steroid treatment. It helps me to get to sleep and sleep more soundly. It also seems to keep me from waking from nighttime aches and pains. I took 50 mg for a long time but now I'm down to 25mg. The most I ever took was 100 mg when still on a steroid taper. It works great, is cheap, old and safe and my MS neuro said it seems to work for MS patients.