thanks for the replies. Here is my scenario, I live in a developing country where docs know even less than is on the net. I do have unlimited access to meds but wont go into that as I was moderated last time.

The reason for my wanting to try topomax is I have water retention and leg/feet swelling from lyrica and neurontin. its frustrating since they do reduce the burn but the intermittent swelling causes another pain altogether

Anyhow, wont hurt to try topomax and i understand nobody here is qualified or allowed to advice. was just throwing out there and may try 50mg after reducing lyrica to 50mg. I have gone cold turkey 300mg lyrica and pulled up okay in the past.

Whats the worst that can happen? I die and no more pain

just kidding..