I have to say I am a bit skeptical.
It sounds like a good idea. But you know patch technology is very very
tricky. Even experienced patch makers have trouble with them.
(TransDerm scop had to be reformulated, for example).
I looked the the parent company...here is the other product they make:
http://www.migravent.com/
There is a dearth of information on their main website:
http://www.vitasciences.com/about-vita-sciences.html
The "clinical trial" is rather amusing:
Quote:
|
A small clinical trial was conducted in August 2003. Six volunteers ( 4 male and 2 female between 20-48) had a baseline blood sample. A B-12 Patch was placed behind the ear of each volunteer after the baseline sample was taken.
|
Not a good study at all!
This article discusses transdermal drug delivery. It also mentions B12:
http://64.233.167.104/search?q=cache...lnk&cd=4&gl=us
B12 is water soluble (hydrophilic) and a large molecule...so the patches have
to be very sophisticated to work successfully.
These patches do not require a doctor's order. They are OTC (over the counter). They are also costly... $ 24.00 for 4.
The scientific data on this patch seem skimpy to me. The diagram is
amateurish looking. I could not find anywhere on the site the amount of drug in that patch --- or the statement as to the type of B12 actually in it.
They ALLUDE to methyl being better than cyano--but they don't STATE that methyl is in it.
Being OTC this is not approved by the FDA... I find the wording on the whole
site to be very clever. Compare the patch data of it to the other
link I gave. A very special formulation for water soluble drugs is necessary and no mention of this special technology is made.
The references this company makes to itself are puzzling. They don't make much...2 products to be exact, and I find the inflated text suspicious.
Pharmaceutical drug delivery products are very sophisticated. This website is not.
I'd like to add that B12 injections do not put the drug directly into the blood stream. They are injected IM or sub Q and absorbed that
way.
Here is an interesting study on how easily oral works:
Quote:
Presse Med. 2005 Mar 12;34(5):358-62. Links
[Low vitamin B12 levels in elderly patients cured within one week by oral cobalamin therapy]
[Article in French]
* Kaltenbach G,
* Andres E,
* Barnier-Figue G,
* Noblet-**** M,
* Noel E,
* Vogel T,
* Perrin AE,
* Berthel M.
Centre de gerontologie, Hopital de la Robertsau, Strasbourg. georges.kaltenbach@chru-strasbourg.fr
OBJECTIVE: Non-dissociation of vitamin B12 from its carrying proteins is the most frequent cause of vitamin B12 deficiency in the elderly. The aim of this study was to determine the initial dose of oral cyanocobalamin that would correct the B12 vitamin deficiency within one week. METHODS: This was an open, prospective, study on 30 elderly patients suffering from vitamin deficiency (B12 < 0.20 microg/L) induced by food-cobalamin malabsorption. Ten patients (group I) were treated with a daily dose of 1000 microg of oral cyanocobalamin (from D1 to D8), 10 (group II) with 1000 microg every other day (D1, D3, D5 and D7), 5 (group III) with 1000 microg every 4 days (D1 and D5) and 5 (group IV) with 1000 microg only on D1. The biological response was assessed by control measurement of vitamin B12 serum levels on the 8th day. RESULTS: Mean vitamin B12 serum levels had significantly increased (p < 0.01) in groups I, II and III, but not in group IV. The dose-effect, assessed by the mean increase in vitamin B12 serum levels, was significantly greater (p < 0.05) in groups I (0.25 microg/L) and II (0.18 microg/L), than in groups III and IV (0.09 microg/L). CONCLUSION: This prospective study shows that an oral dose of 1000 microg of cyanocobalamin every 4 days, which corresponds to 250 microg per day, was sufficient to correct B12 vitamin deficiency induced by food-cobalamin malabsorption within one week. However, initial doses of 1000 microg per day or every other day would be preferable because of the greater dose-effect with daily doses higher than 500 microg. A randomised study is warranted to validate these preliminary results.
PMID: 15859569 [PubMed - indexed for MEDLINE]
|
9 cents a day or $2.70 a month compared to $24.99 a month for 4 patches(assuming they work of course). You choose.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.