has come up before. For many years the HIV community has used
acetyl-l-carnitine ( an amino acid) to help with drug induced PN.
Here is a study on chemo:
Quote:
In Vivo. 2005 May-Jun;19(3):631-7. Links
Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine.
* Ghirardi O,
* Vertechy M,
* Vesci L,
* Canta A,
* Nicolini G,
* Galbiati S,
* Ciogli C,
* Quattrini G,
* Pisano C,
* Cundari S,
* Rigamonti LM.
Research and Development, Sigma-Tau S.p.A. Industrie Farmaceutiche Riunite, Rome, Italy. orlando.ghirardi@sigma.tau.it
BACKGROUND: We tested the hypothesis that acetyl-L-carnitine (ALC) may have a protective and a curative role in chemotherapy-induced hyperalgesia in vivo, in animal models of cisplatin-, paclitaxel- and vincristine-induced neuropathy. In addition, the possible interaction between ALC and vincristine antineoplastic action was assessed. MATERIALS AND METHODS: Chemotherapy-induced peripheral neuropathy (CIPN) was induced in different groups of rats. The effect of ALC was evaluated both when its administration was started together with the administration of anticancer drugs ("preventive" protocol) and when ALC administration was started later on during treatment ("curative" protocol). RESULTS: The ALC treatment significantly prevented the lowering of the mechanical nociceptive threshold when the administration started concomitantly and, respectively, with cisplatin, paclitaxel and vincristine as compared to each drug alone. Furthermore, when ALC administration was started later on during treatment, at well-established neuropathy, ALC was able to restore the mechanical nociceptive threshold within a few days. Finally, experiments indicated that ALC does not interfere with the antitumor effects of vincristine. CONCLUSION: Considering the absence of any satisfactory treatment currently available for CIPN in a clinical setting, these are important observations, opening up the possibility of using ALC to treat a wide range of patients who have undergone chemotherapy and developed sensory peripheral neuropathy.
PMID: 15875786 [PubMed - indexed for MEDLINE]
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To help repair damaged nerves.. one needs B12, B-complex and
Essential fatty acids (mostly fish oil) to provide the nutrients to repair.
Magnesium helps too, with this function.
The acetyl-l-carnitine helps with mitochondrial cellular energy issues.
The fact that the hands have improved, but the feet not, implies at least to me that improving circulation will help get the nutients to that long haul
down there. Soaking in warm epsom salts helps, do that, as well as keeping feet elevated as much as possible, and keeping the feet from getting "cold".
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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