Rachel, According to the basic science of the body, acetylcholinesterase increases in both hot and cold temperatures. When that enzyme increases, it "eats up" even more acetylcholine. So it can make you weaker to be in hot or cold weather.

I've cited articles in previous posts but don't have energy to do it now. You can Google "acetylcholinesterase temperature" and see what you get. There is a lot to learn about MG.

I didn't find any articles about "relative" temperature changes though. Like if your body goes from 80 to 60, or vice versa.

Annie