I would just like to add: .5mg (500mcg) is not a tiny dose.
Estradiol comes orally in .5mg (500mcg), 1mg and 2mg for hormone replacement. .5mg just happens to be the smallest of the 3 doses used for hormone replacement. The patches for this drug bypass the liver and are much lower in dose. They are in the microgram range.
Compared to most birth control pills which have about .035mg of estradiol which is 35mcg. (Ortho Cyclen) or like the newer Yaz which is 20mcg, and LoEstrin which is 20mcg also.
I believe that the .5mg dose is a considerable amount of potent estrogen (estradiol is the most potent biologically active form).
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Weezie looking at petunias 8.25.2017
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