After being diagnosed with MG in Dec. 2008 my teatments starting early in2009 have been 2 monthly IVIG's per month, 2000 mg of cellcept x2. 60 mg of mestinon x5 and prednisone 120 mg every other day. I have said before I have expieriencied everything this desease has to offer.

Fast forward to Feb. 2010. Significant inprovement. That's when my neuro started reducing my pred intake. First 100 mg EOD, then 80, ect., and last month from 20 mg to 15 mg EOD.

When I went from 40 to 20 mg EOD, I started increased fatigue. Now it is much worse and I am unable to do a lot of the things I did earlier in this year. For example, I could go out in the evening maybe for dinner or for a get together or play some cards. Now getting out of my chair in the evenings is quite a chore. My days can be like this also.

I have read a lot of posts about tapering off of pred, but no mention if the tapering resulted in more fatigue. Wondering if anybody else has had this happen to them.

Could be the reduction of pred has nothing to do with the way I am feeling but the damage the pred is has done to my body. Osteoporosis and osteoarthritis.

Any thoughts.

Tony