Thread: So which "existing" diabetes drug turns the PGC-1 Alpha "Master Switch" back on?
View Single Post
Old 10-06-2010, 09:24 PM
Conductor71's Avatar
Conductor71 Conductor71 is offline
Senior Member
  
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Conductor71 Conductor71 is offline
Senior Member
Conductor71's Avatar
 
Join Date: Jul 2009
Location: Michigan
Posts: 1,474
10 yr Member
Default Good question
Quote:
Originally Posted by caldeerster View Post
Possibly this one?

http://jap.physiology.org/cgi/content/full/101/6/1685

Metformin increases the PGC-1 protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo

http://en.wikipedia.org/wiki/Metformin
I am thinking this class of drugs:

Thiazolidinediones one of which is Pioglitazone which I remembered seeing that it was a diabetic drug that held promise for treating Parkinson's

Here is an article on it from 2006

I find it interesting that we have an endocrine link...who is it here that strongly feels PD is linked to insulin metabolism...is it Bluedhalia?

Laura
Conductor71 is offline   Reply With QuoteReply With Quote