Thread: So which "existing" diabetes drug turns the PGC-1 Alpha "Master Switch" back on?
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Old 10-08-2010, 09:25 AM
paula_w paula_w is offline
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paula_w paula_w is offline
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Published online 6 October 2010 | Nature | doi:10.1038/news.2010.518

News
Damaged cell powerhouses linked to Parkinson's
New uses for old drugs

Such drugs have already been widely pursued as potential therapies for type 2 diabetes, and some have already been approved for that use. Avandia (rosiglitazone), a diabetes drug recently pulled from the European market because it raises the risk of heart attack, activates a key protein in the PGC-1α pathway.

But a related drug called Actos (pioglitazone) has not been firmly linked to heart attack and remains in use. Beal says that a clinical trial to test Actos in patients with Parkinson's disease has already been approved by regulators.

http://www.nature.com/news/2010/1010....2010.518.html

no mention of metformin altho it sounds safe for diabetes.
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Last edited by paula_w; 10-08-2010 at 09:29 AM. Reason: duh just read laura's again...same study
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