I have CRPS in both legs from hip to toe and about three months ago my Dr prescribed Savella. I had to tirate the dose and slowly worked up to 100millagrams once a day. I did experience the following side effects: increase in blood preasure, nausea and sweating episodes. The b.p and nausea subsided after a couple weeks and the sweating stopped roughly a month later. The Savella was prescribed to help with the muscle pain (Opiates do not help with the muscle pain and I could barely walk). The Savella worked great and I think it is one of the best medicines that I have tried (and I have tried cymbalta, gabapentin, flexoral, ect.) When my dose was increasing I was told to cut back the dose if I became to nausea's but to increase the dose slowly over a two week period. If the side effects are too strong then they recommended staying at 50mg a day but I was able to get to 100mg because I thought the side effects were worth the benefit. Hope this helps and let me know if you have any other questions.
Sarah