Originally Posted by Natalie8

Please see this for the actual verbatim report from the Archives of Neurology.
http://archneur.ama-assn.org/cgi/con...rol.2010.257v1

Two things to take note of:
1. "Overall, relapses occurred more often in younger patients with fewer natalizumab infusions prior to therapy interruption."
2. Many of the patients with rebound activity had "disease refractive to multiple therapeutics before starting natalizumab treatment." In other words, these were people with aggressive MS from the very beginning who failed on other drugs.

When and if I go off Tysabri, my doctor has a plan. I will be off Tysabri for 90 days before starting a new drug (which will likely be Gilenya). However, on the 60th day of this 90 day break I will be given one dose of IV steroids at 1,000 mg. The steroids are designed to limit risk of inflammatory rebound during the transition.