Wow! Thanks for posting this. This seems watershed to me as no one could explain the paradoxica kinesia or why only our normal everyday movements were affected but not things like riding a bike. I think we had a thread on this a while back. I was beginning to think it was partly a memory issue, but this explains it as all physiological. The next logical question they ask is one we've asked many times here. Why are those particular dopaminergic neurons more vulnerable than others? This finding could provide clues that really get us closer to the actual causes involved. Maybe they are somehow more closely connected to the olfactory and vagus nerves that show in Braak's staging as an early manifestation of the disease.

This is one to watch.

Laura