http://www.benbest.com/science/anatm...html#glutamate

This is the most complicated transmitter and always excitatory. I defer to the links for more explanation. The link below, however, demonstrates progress in its therapeutic potential and is a pretty important discovery.

Glutamate is considered to be a critical transmitter that has abnormal signaling in parkinson's and other movement circuit conditions.


http://www.dddmag.com/article-Glutam...py-101310.aspx

This one is in therapeutic experimentation. From the article a most promising find:

ADX48621, an mGluR5 NAM being developed by Addex Pharmaceuticals has shown efficacy in a non-human primate model of PD-LID.5

These data suggest that ADX48621 is differentiated and shows considerable efficacy on both components of dyskinesia–chorea and dystonia.

Indeed, we believe ADX48621 is the first and only product to have been reported to have efficacy on dystonia in this model of PD-LID.

ADX48621 has completed Phase 1 testing and is initiating one study for ADX48621 in PD-LID patients and a second study for ADX48621 in patients with dystonia.

[pd-lid] = pd levodopa induced dystonia.