Michael Mac,
I too am on the patch and had started it on a three day cycle and I noticed that the later part of the 2nd day that the adhesive part of the patch was cutting my skin. By the third day the patch either would fall off or I had to take it off because it would hurt my skin so much. Either way if the patch managed to stay on for three days I noticed a significant difference in my pain levels as it didn't provide as much relief. I noticed that the directions also call for the 3M Tegraderm patch cover. I had to purchase the Tegrederm cover from the pharmacy and they were slightly expensive but the difference was night and day with the pain relief. The 3M patch makes the patch stay adhere to your skin which made the patch work the full time. (30 covers lasted two to three months because one cover can cover 3-5 patches because they are so large.)
But even with the 3M cover I had to go to every 48hrs because the patch cut my skin. My Dr changed the script to every 48hrs and said that my skin appears to be allergic to the which is why it was cutting my skin and why it didnt work for me on the third day. Sorry for the length and hang in there.