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In Remembrance
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Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
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In Remembrance
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
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Neurons just inactive,
ie not dead. THis is something I have felt for a long time. For example, so many of us report being more mobile after a good nights sleep.
Laura, so much of the information you post above confirms we still have the ability to generate dopamine, if it can be awakened.
Rick, your refs fit in very well,
"Our data suggest that curcumin inhibits AS (alpha synuclein) oligomerization into higher
molecular weight aggregates and therefore should be further explored as a
potential therapeutic compound for PD and related disorders."
" RESULTS: Here we show that
curcumin can alleviate alphaS-induced toxicity, reduce ROS levels and protect
cells against apoptosis."
Curcumin is not an immediate overnight miracle, it seems to need regular doses over a long period to have an effect. It does seem to stop AS from polymerising into oligomers (polymers formed from 2, 3 or 4 monomers), which then block the dopamine neurons.
A quick search showed swallowing does have an effect on brain chemistry, but I have not found data yet to show dopamine production is enhanced.
Ron
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Diagnosed Nov 1991.
Born 1936
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