Originally Posted by suev

A few things to know about Mestinon...

it effectively lasts about 4 hours - - so if you are taking it twice a day - you are probably 'running on empty' for some hours of the day

it's absolutely best to take it with some food - candy bars don't really qualify, the sugar alone could make anyone anxious

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Yes, you are right about this. I was out and didn't have anything else with me. I probably should have waited until I got home to take it with something decent. I do think that the reaction was mostly because I hadn't eaten anything in about five hours. I really need to eat more often.

For reasons that I do not know, I was pretty sensitive to Mestinon in the beginning and could 'feel it' kick in...and I was kind of anxious about what I was feeling. After almost 18 months of taking it, I rarely get that feeling anymore even though I now take higher doses

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I think I can tell when it kicks in too! And, because I've had reactions to meds in the past I think I am extra sensitive to the physical feelings. It's good to know that this could pass in time. If anything, maybe I'll get use to the feeling and it wont scare me so much.

As far as how do you know if it's working? Mostly I know when it isn't - not when it is. If I need more (like when it is getting close to time to take it) - I'm still functioning fine. I'm just exerting more will power to do whatever I'm doing! I could keep going without it - but by the end of the day I would be droopy and tired...and I would be concentrating and using two hands to get the gallon of milk out of fridge - instead of just grabbing the milk!!