Sue gave you some very good info. I have a similar problem with sodium, lymphs, etc. but my background of having diabetes insipidus (lack of antidiuretic hormone) and being given too many fluids while on the drug for that started my problems (capillary permeability). I have generalized edema due to that, though not super bad.

Ankle swelling is NOT normal. The doctors who start the process of evaluating that are cardiologists. I highly suggest you see one as soon as possible. In fact, due to the high prevalence of people who have autoimmune diseases and also have the clotting disorder APS (antiphospholipid syndrome), I suggest you see your primary pronto so they can rule out a clot/DVT.

It is most definitely NOT a little known symptom of MG. When it is localized like that, the cause is more than likely circulatory in nature. PLEASE seek out help right away.

Annie