Lindy,

I am really interested in the genetic component because I have two generations, well three actually if I count myself. on my dad's side with undiagnosed tremor

I read recently that they think that Young Onset people generally have a strong genetic component. I have seen figures that say 30-40 % and some as high as 50 % of YO have a genetic mutation. I can't for the life of me understand how they get these numbers given no one can even say for sure how many people worldwide have PD. Then I wonder just who are they testing? Certainly not me. I also wonder how many of us have genetic variants but go unaccounted for? I have read they now have 13-14 Parkin mutations, yet maybe only one or two they can test reliably for at a general lab. Frustrating as I'd like to know for my son's sake what is up.

It does seem that we have rather delicate systems or our BBB is like a sieve or something. It is odd that something so ubiquitous as particulate matter could be the start of something so complex.

Laura