I am not an expert but I think it varies from person to person. I know my gramps has had neuropathy for many years and now he is almost 88 and is still active. He has a hard time long distances but overall especially for his age doing well. I think part of the importance of finding out the why behind the neuropathy is so it can get to a better point or stop it from getting worse. You said you are getting b12 shots was your's low? Some people on here who had low b12 levels and then got them to a better place have felt benefits.