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Old 02-17-2007, 12:50 PM
DJM1 DJM1 is offline
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Join Date: Sep 2006
Location: Colorado
Posts: 45
15 yr Member
DJM1 DJM1 is offline
Junior Member
 
Join Date: Sep 2006
Location: Colorado
Posts: 45
15 yr Member
Default Risk of Sudden Sinemet Withdrawal

Yes, thank you! That was the condition I was referring to.

"Sinemet has been associated with a syndrome resembling neuroleptic malignant syndrome on withdrawal or significant dosage reduction after long-term use."

From The National Institute for Neurological Diseases and Stroke (NINDS):

What is Neuroleptic Malignant Syndrome?
Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

Is there any treatment?
Generally, intensive care is needed. The neuroleptic or antipsychotic drug is discontinued, and the fever is treated aggressively. A muscle relaxant may be prescribed. Dopaminergic drugs, such as a dopamine agonist, have been reported to be useful.

What is the prognosis?
Early identification of and treatment for individuals with neuroleptic malignant syndrome improves outcome. If clinically indicated, a low potency neuroleptic can be reintroduced very slowly when the individual recovers, although there is a risk that the syndrome might recur. Another alternative is to substitute another class of drugs for the neuroleptic. Anesthesia may be a risk to individuals who have experienced neuroleptic malignant syndrome.

Last edited by DJM1; 02-17-2007 at 01:06 PM. Reason: Add NINDS info
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